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Updated results of the United Kingdom linkage-based genome screen in multiple sclerosis

Hensiek, A.E., Roxburgh, R., Smilie, B., Coraddu, F., Åkesson, E., Holmans, Peter Alan ORCID:, Sawcer, S.J. and Compston, D.A.S. 2003. Updated results of the United Kingdom linkage-based genome screen in multiple sclerosis. Journal of Neuroimmunology 143 (1-2) , pp. 25-30. 10.1016/j.jneuroim.2003.08.007

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In 1996, we reported the results of a linkage genome screen based on 129 UK multiple sclerosis multiplex families, together with follow-up typing of interesting regions in a second set of families. We have now completed screening the remainder of the genome in this second set of United Kingdom families by typing 242 microsatellite markers. These data have been analysed together with those previously published, resulting in the largest currently available whole genome linkage dataset from a single population in multiple sclerosis. Four new regions of potential linkage (chromosomes 10p, 11p, 19p, 20p) not previously described were identified. In the combined analysis of all 226 families, a total of five regions of suggestive linkage are seen (chromosomes 1p, 6p, 14q, 17q, Xq), where only one would have been expected to occur by chance alone.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: R Medicine > R Medicine (General)
Publisher: Elsevier
ISSN: 0165-5728
Last Modified: 31 Oct 2022 09:40

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