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The T-cell receptor beta locus and susceptibility to multiple sclerosis

Wood, N. W., Sawcer, S. J., Kellar-Wood, H. F., Holmans, Peter Alan ORCID:, Clayton, D., Robertson, Neil ORCID: and Compston, D. A. 1995. The T-cell receptor beta locus and susceptibility to multiple sclerosis. Neurology 45 (10) , pp. 1859-1863. 10.1212/WNL.45.10.1859

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(7q32-35) in multiplex MS families. Affected sibling-pair analysis of the RFLP data failed to show evidence for linkage (127 families) whereas analysis of the microsatellite data (86 families) provided weak evidence for linkage with a maximum lod score of 0.98 (p < 0.05). We repeated the analysis in those families (n = 53) in which the affected sibling pairs were concordant for the HLA haplotype DR15/DQ6. This altered the proportion of affected siblings sharing 0, 1, 2 RFLP haplotypes from 0.24, 0.50, and 0.26 (p = NS) before stratification to 0.16, 0.41, and 0.43 (p < 0.05) in the DR15/DQ6 positive pairs alone; for the microsatellite data, sharing altered from 0.16, 0.50, and 0.34 (p < 0.05) in all pairs to 0.07, 0.49, and 0.44 (p < 0.01) in the DR15/DQ6 concordant siblings.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: R Medicine > R Medicine (General)
Publisher: Lippincott Williams & Wilkins
ISSN: 0028-3878
Last Modified: 17 Nov 2022 12:38

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