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Seizure induced dentate neurogenesis does not diminish with age in rats

Gray, William Peter ORCID:, May, K and Sundström, L. E. 2002. Seizure induced dentate neurogenesis does not diminish with age in rats. Neuroscience Letters 330 (3) , pp. 235-238. 10.1016/S0304-3940(02)00810-8

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Neurogenesis in the mammalian dentate gyrus occurs throughout life, is believed to be important for the laying down of episodic memory and diminishes significantly with increasing age. Pathological insults such as seizures, hypoxia and traumatic brain injury increase dentate neurogenesis compared to age matched controls. Using unilateral intracerebroventricular kainate we show that although baseline neurogenesis is significantly lower in 3 month old rats compared to 1 month old rats, kainate increases neurogenesis to reach similar levels in both age groups. Additionally, this effect is bilateral after a unilateral intracerebroventricular kainate injection. We conclude that the potential for dentate neurogenesis is maintained despite diminishing baseline levels with increasing age and that injury signals override the age related suppression of neurogenesis.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: Elsevier
ISSN: 0304-3940
Last Modified: 31 Oct 2022 09:55

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