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A Quantitative Trait Locus Associated With Cognitive Ability in Children

Chorney, M.J., Chorney, K., Seese, N., Owen, Michael John ORCID:, Daniels, J., McGuffin, P., Thompson, L.A., Detterman, D.K., Benbow, C., Lubinski, D., Eley, T. and Plomin, R. 1998. A Quantitative Trait Locus Associated With Cognitive Ability in Children. Psychological Science 9 (3) , pp. 159-166. 10.1111/1467-9280.00032

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Quantitative trait loci (QTLs) associated with general cognitive ability (g) were investigated for several groups of children selected for very high or for average cognitive functioning. A DNA marker in the gene for insulin-like growth factor-2 receptor (IGF2R) on Chromosome 6 yielded a significantly greater frequency of a particular form of the gene (allele) in a high-g group (.303; average IQ = 136, N = 51) than in a control group (.156, average IQ = 103, N = 51). This association was replicated in an extremely-high-g group (all estimated IQs > 160, N = 52) as compared with an independent control group (average IQ = 101, N = 50), with allelic frequencies of .340 and .169, respectively. Moreover, a high-mathematics-ability group (N = 62) and a high-verbal-ability group (N = 51) yielded results that were in the same direction but only marginally significant (p = .06 and .08, respectively).

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
Publisher: Blackwell
ISSN: 09567976
Last Modified: 31 Oct 2022 09:55

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