Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

A genome-wide screen for linkage in Nordic sib-pairs with multiple sclerosis

Akesson, E, Oturai, A, Berg, J, Fredrikson, S, Andersen, O, Harbo, H F, Laaksonen, M, Myhr, K M, Nyland, H I, Ryder, L P, Sandberg-Wollheim, M, Sorensen, P S, Spurkland, A, Svejgaard, A, Holmans, Peter ORCID:, Compston, A, Hillert, J and Sawcer, S 2002. A genome-wide screen for linkage in Nordic sib-pairs with multiple sclerosis. Genes and Immunity 3 (5) , pp. 279-285. 10.1038/sj.gene.6363866

Full text not available from this repository.


Genetic factors influence susceptibility to multiple sclerosis but the responsible genes remain largely undefined, association with MHC class II alleles being the only established genetic feature of the disease. The Nordic countries have a high prevalence of multiple sclerosis, and to further explore the genetic background of the disease, we have carried out a genome-wide screen for linkage in 136 sibling-pairs with multiple sclerosis from Denmark, Finland, Norway and Sweden by typing 399 microsatellite markers. Seventeen regions where the lod score exceeds the nominal 5% significance threshold (0.7) were identified—1q11–24, 2q24–32, 3p26.3, 3q21.1, 4q12, 6p25.3, 6p21–22, 6q21, 9q34.3, 10p15, 10p12–13, 11p15.5, 12q21.3, 16p13.3, 17q25.3, 22q12–13 and Xp22.3. Although none of these regions reaches the level of genome-wide significance, the number observed exceeds the 10 that would be expected by chance alone. Our results significantly add to the growing body of linkage data relating to multiple sclerosis.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: R Medicine > R Medicine (General)
Publisher: Nature Publishing Group
ISSN: 1466-4879
Last Modified: 31 Oct 2022 09:56

Citation Data

Cited 71 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item