The contribution of gene-environment interaction to psychopathology

Thapar, Anita ORCID: https://orcid.org/0000-0002-3689-737X, Harold, Gordon Thomas, Rice, Frances ORCID: https://orcid.org/0000-0002-9484-1729, Langley, Kate ORCID: https://orcid.org/0000-0002-2033-2657 and O'Donovan, Michael Conlon ORCID: https://orcid.org/0000-0001-7073-2379 2007. The contribution of gene-environment interaction to psychopathology. Development and Psychopathology 19 (04) , pp. 989-1004. 10.1017/S0954579407000491

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Abstract

The study of gene-environment interaction (G x E) constitutes an area of significant social and clinical significance. Different types of research study designs are being used to investigate the contribution of G x E to psychopathology, although the term G x E has also been used and interpreted in different ways. Despite mixed evidence that G x E contributes to psychopathology, some promising and consistent findings are emerging. Evidence is reviewed in relation to depression, antisocial behavior, schizophrenia, and attention-deficit/hyperactivity disorder. Although findings from various research designs have different meaning, interestingly much of the evidence with regard to the contribution of G x E that has arisen from twin and adoption studies has been for antisocial behavior and depression. It is for these same forms of psychopathology that molecular genetic evidence of G x E has also been most convincing. Finally, current and anticipated methodological challenges and implications for future research in this area are considered.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > R Medicine (General)
Publisher:	Cambridge University Press
ISSN:	0954-5794
Last Modified:	17 Oct 2023 11:27
URI:	https://orca.cardiff.ac.uk/id/eprint/82993

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