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The contribution of gene-environment interaction to psychopathology

Thapar, Anita ORCID:, Harold, Gordon Thomas, Rice, Frances ORCID:, Langley, Kate ORCID: and O'Donovan, Michael Conlon ORCID: 2007. The contribution of gene-environment interaction to psychopathology. Development and Psychopathology 19 (04) , pp. 989-1004. 10.1017/S0954579407000491

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The study of gene-environment interaction (G x E) constitutes an area of significant social and clinical significance. Different types of research study designs are being used to investigate the contribution of G x E to psychopathology, although the term G x E has also been used and interpreted in different ways. Despite mixed evidence that G x E contributes to psychopathology, some promising and consistent findings are emerging. Evidence is reviewed in relation to depression, antisocial behavior, schizophrenia, and attention-deficit/hyperactivity disorder. Although findings from various research designs have different meaning, interestingly much of the evidence with regard to the contribution of G x E that has arisen from twin and adoption studies has been for antisocial behavior and depression. It is for these same forms of psychopathology that molecular genetic evidence of G x E has also been most convincing. Finally, current and anticipated methodological challenges and implications for future research in this area are considered.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
Publisher: Cambridge University Press
ISSN: 0954-5794
Last Modified: 17 Oct 2023 11:27

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