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No evidence for association between polymorphisms in GRM3 and schizophrenia

Norton, Nadine, Williams, Hywel, Dwyer, Sarah, Ivanov, Dobril ORCID:, Preece, Anna, Gerrish, Amy, Williams, Nigel Melville ORCID:, Yerassimou, P., Zammit, Stanley ORCID:, O'Donovan, Michael Conlon ORCID: and Owen, Michael John ORCID: 2005. No evidence for association between polymorphisms in GRM3 and schizophrenia. BMC Psychiatry 5 , 23. 10.1186/1471-244X-5-23

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BACKGROUND: Three studies have previously reported data that were interpreted by the authors as supportive of association between schizophrenia and polymorphisms in the gene encoding the metabotropic glutamate receptor GRM3. METHODS: In a bid to examine this hypothesis, we examined seven SNPs spanning GRM3 in a UK case-control sample (schizophrenic cases n = 674, controls n = 716). These included all SNPs previously reported to be associated, alone or in haplotypes, with schizophrenia in European or European American samples. RESULTS: Our data showed no evidence for association with single markers, or 2, 3, 4 and 5 marker haplotypes, nor did any specific haplotypes show evidence for association according to previously observed patterns. CONCLUSION: Examination of our own data and those of other groups leads us to conclude that at present, GRM3 should not be viewed as a gene for which there is replicated evidence for association with schizophrenia.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
Publisher: BioMed Central
ISSN: 1471-244X
Date of First Compliant Deposit: 22 August 2018
Last Modified: 05 Jan 2024 04:43

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