No evidence of association between Catechol-O-Methyltransferase (COMT) Val(158)Met genotype and performance on neuropsychological tasks in children with ADHD: A case-control study

Mills, Sophie, Langley, Kate ORCID: https://orcid.org/0000-0002-2033-2657, van den Bree, Marianne Bernadette ORCID: https://orcid.org/0000-0002-4426-3254, Street, Eddy, Turic, Darko, Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862, O'Donovan, Michael Conlon ORCID: https://orcid.org/0000-0001-7073-2379 and Thapar, Anita ORCID: https://orcid.org/0000-0002-3689-737X 2004. No evidence of association between Catechol-O-Methyltransferase (COMT) Val(158)Met genotype and performance on neuropsychological tasks in children with ADHD: A case-control study. BMC Psychiatry 4 , p. 15. 10.1186/1471-244X-4-15

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Abstract

Background Several studies have suggested an association between the functionalVal 158 Met polymorphism in theCatechol-O-Methyltransferase (COMT) gene and neurocognitive performance. Two studies showed that subjects with the low activityMet allele performed better on the Wisconsin Card Sorting Test (WCST) and another study found an effect on processing speed and attention. Methods We set out to examine the association between theVal 158 Met polymorphism and performance on neurocognitive tasks including those tapping working memory, attention and speed, impulsiveness and response inhibition in a sample of 124 children with ADHD. Task performance for each genotypic group was compared using analysis of variance. Results There was no evidence of association with performance on any of the neurocognitive tasks. Conclusions We conclude that Val 158 Met COMT genotype is not associated with neurocognitive performance in our sample.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Psychology MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > R Medicine (General)
Publisher:	BioMed Central
ISSN:	1471-244X
Last Modified:	17 Nov 2022 13:30
URI:	https://orca.cardiff.ac.uk/id/eprint/83506

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