Young onset limb spasticity with PSP-like brain and spinal cord NFT-tau pathology

Papapetropoulos, S., Scaravilli, T., Morris, Huw, An, S. F., Henderson, D. C., Quinn, N. P., Scaravilli, F. and Bhatia, K. P. 2005. Young onset limb spasticity with PSP-like brain and spinal cord NFT-tau pathology. Neurology 64 (4) , pp. 731-733. 10.1212/01.WNL.0000150622.87222.12

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Abstract

A 30-year-old white man presented with a sporadic form of gradually progressive spastic gait and, later, supranuclear vertical and horizontal gaze palsy, mild cognitive impairment, loss of postural reflexes, and falls. DNA analysis revealed H1/H1 haplotype without tau gene (exons 9 to 13) mutation. Eight years later, postmortem revealed a tauopathy similar to progressive supranuclear palsy. Unusual aspects were early age at onset, neurofibrillary tangle, and tau involvement of the cord.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Mathematics
Subjects:	R Medicine > R Medicine (General)
Publisher:	Lippincott Williams & Wilkins
ISSN:	0028-3878
Last Modified:	10 Dec 2015 10:26
URI:	https://orca.cardiff.ac.uk/id/eprint/83579

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