Genetics of Parkinson's disease

Morris, Huw 2005. Genetics of Parkinson's disease. Annals of Medicine 37 (2) , pp. 86-96. 10.1080/07853890510007269

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Abstract

Twenty years ago Parkinson's disease (PD) was thought of as an environmentally determined neurodegenerative disease. It is now known that there are two autosomal dominant disease genes, alpha-synuclein and dardarin, and three genes responsible for autosomal recessive PD, parkin, DJ-1 and PINK-1. Although these gene mutations are not common, their identification has led to a new understanding of the pathogenesis of PD, and to a development in the understanding of the clinical and pathological definitions of PD and Lewy body disease. Ultimately, these advances may lead to the development of new disease-modifying therapies, but more immediately these discoveries have led to a more coherent view of the spectrum of PD and Lewy body diseases and to accurate genetic diagnosis and counselling for some families.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Publisher:	Informa Healthcare
ISSN:	0785-3890
Last Modified:	10 Dec 2015 13:56
URI:	https://orca.cardiff.ac.uk/id/eprint/83635

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