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Efflux pump induction by quaternary ammonium compounds and fluoroquinolone resistance in bacteria

Buffet-Bataillon, Sylvie, Tattevin, Pierre, Maillard, Jean-Yves ORCID:, Bonnaure-Mallet, Martine and Jolivet-Gougeon, Anne 2016. Efflux pump induction by quaternary ammonium compounds and fluoroquinolone resistance in bacteria. Future Microbiology 11 (1) , pp. 81-92. 10.2217/fmb.15.131

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Biocides, primarily those containing quaternary ammonium compounds (QAC), are heavily used in hospital environments and various industries (e.g., food, water, cosmetic). To date, little attention has been paid to potential implications of QAC use in the emergence of antibiotic resistance, especially fluoroquinolone-resistant bacteria in patients and in the environment. QAC-induced overexpression of efflux pumps can lead to: cross resistance with fluoroquinolones mediated by multidrug efflux pumps; stress response facilitating mutation in the Quinolone Resistance Determining Region; and biofilm formation increasing the risk of transfer of mobile genetic elements carrying fluoroquinolone or QAC resistance determinants. By following the European Biocidal Product Regulation, manufacturers of QAC are required to ensure that their QAC-based biocidal products are safe and will not contribute to emerging bacterial resistance.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Subjects: R Medicine > RM Therapeutics. Pharmacology
Publisher: Future Medicine
ISSN: 1746-0913
Date of First Compliant Deposit: 30 March 2016
Date of Acceptance: 21 October 2015
Last Modified: 06 Nov 2023 21:12

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