Evaluating historical candidate genes for schizophrenia

Farrell, M S, Werge, T, Sklar, P, Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862, Ophoff, R A, O'Donovan, Michael Conlon ORCID: https://orcid.org/0000-0001-7073-2379, Corvin, A, Cichon, S and Sullivan, P F 2015. Evaluating historical candidate genes for schizophrenia. Molecular Psychiatry 20 (5) , pp. 555-562. 10.1038/mp.2015.16

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Abstract

Prior to the genome-wide association era, candidate gene studies were a major approach in schizophrenia genetics. In this invited review, we consider the current status of 25 historical candidate genes for schizophrenia (for example, COMT, DISC1, DTNBP1 and NRG1). The initial study for 24 of these genes explicitly evaluated common variant hypotheses about schizophrenia. Our evaluation included a meta-analysis of the candidate gene literature, incorporation of the results of the largest genomic study yet published for schizophrenia, ratings from informed researchers who have published on these genes, and ratings from 24 schizophrenia geneticists. On the basis of current empirical evidence and mostly consensual assessments of informed opinion, it appears that the historical candidate gene literature did not yield clear insights into the genetic basis of schizophrenia. A likely reason why historical candidate gene studies did not achieve their primary aims is inadequate statistical power. However, the considerable efforts embodied in these early studies unquestionably set the stage for current successes in genomic approaches to schizophrenia.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > R Medicine (General)
Publisher:	Nature Publishing Group
ISSN:	1359-4184
Date of Acceptance:	5 January 2015
Last Modified:	31 Oct 2022 10:25
URI:	https://orca.cardiff.ac.uk/id/eprint/84797

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