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A multistep continuous flow synthesis machine for the preparation of pyrazoles via a metal-free amine-redox process

Poh, Jian-Siang, Browne, Duncan L. and Ley, Steven V. 2016. A multistep continuous flow synthesis machine for the preparation of pyrazoles via a metal-free amine-redox process. Reaction Chemistry and Engineering 2016 (1) , pp. 101-105. 10.1039/C5RE00082C

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Abstract

A versatile multistep continuous flow setup is reported for the four-step conversion of anilines into pyrazole products. The synthesis machine incorporates the use of amine-redox chemistry through diazotization and a metal-free vitamin C mediated reduction. The machine can be used for the synthesis of an array of analogues or the scale up of an individual target.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Subjects: Q Science > QD Chemistry
Publisher: Royal Society of Chemistry
ISSN: 2058-9883
Funders: Engineering and Physical Sciences Research Council
Date of First Compliant Deposit: 3 July 2017
Date of Acceptance: 23 November 2015
Last Modified: 06 Jan 2021 02:37
URI: https://orca.cardiff.ac.uk/id/eprint/84888

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