Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Psychogenic and neural visual-cue response in PD dopamine dysregulation syndrome

Loane, Clare, Wu, Kit, O'Sullivan, Sean S., Lawrence, Andrew David ORCID:, Woodhead, Zoe, Lees, Andrew J., Piccini, Paola and Politis, Marios 2015. Psychogenic and neural visual-cue response in PD dopamine dysregulation syndrome. Parkinsonism & Related Disorders 21 (11) , pp. 1336-1341. 10.1016/j.parkreldis.2015.09.042

Full text not available from this repository.


Introduction Dopamine dysregulation syndrome (DDS) in Parkinson's disease (PD) patients refers to the compulsive use of dopaminergic replacement therapy and has serious psycho-social consequences. Mechanisms underlying DDS are not clear although has been linked to dysfunctional brain reward networks. Methods With fMRI, we investigate behavioral and neural response to drug-cues in six PD DDS patients and 12 PD control patients in both the ON and OFF medication state. Behavioral measures of liking, wanting and subjectively ‘feeling ON medication’ were also collected. Results Behaviorally, PD DDS patients feel less ON and want their drugs more at baseline compared to PD controls. Following drug-cue exposure, PD DDS patients feel significantly more ON medication, which correlates with significant increases in reward related regions. Conclusions The results demonstrate that exposure to drug-cues increases the subjective feeling of being ‘ON’ medication which corresponds to dysfunctional activation in reward related regions in PD DDS patients. These findings should be extended in future studies. Visual stimuli being sufficient to elicit behavioral response through neuroadaptations could have direct implications to the management of addictive behavior.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Psychology
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: Parkinson's disease; Addiction; fMRI; Dopamine dyregulation syndrome; Reward; Psychiatry
Publisher: Elsevier
ISSN: 1353-8020
Date of Acceptance: 20 September 2015
Last Modified: 31 Oct 2022 10:29

Citation Data

Cited 8 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item