Transcranial modulation of brain oscillatory responses: A concurrent tDCS-MEG investigation

Hanley, Claire J., Singh, Krish D. ORCID: https://orcid.org/0000-0002-3094-2475 and McGonigle, David J. ORCID: https://orcid.org/0000-0001-9595-6352 2016. Transcranial modulation of brain oscillatory responses: A concurrent tDCS-MEG investigation. NeuroImage 140 , pp. 20-32. 10.1016/j.neuroimage.2015.12.021

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Abstract

Despite the increasing use of transcranial direct current stimulation (tDCS), the physiological mechanisms underlying its effects are still largely unknown. One approach to directly investigate the effects of the neuromodulation technique on the brain is to integrate tDCS with non-invasive neuroimaging in humans. To provide new insight into the neurobiology of the method, DC stimulation (1 mA, 600 s) was applied concurrently with Magnetoencephalography (MEG), while participants engaged in a visuomotor task before, during and after a period of tDCS. Responses in the motor beta band (15–30 Hz) and visual gamma band (30–80 Hz) were localised using Synthetic Aperture Magnetometry (SAM). The resulting induced and evoked oscillatory responses were subsequently analysed. A statistically significant reduction of average power in the visual gamma band was observed for anodal compared to sham stimulation. The magnitude of motor evoked responses was also found to be significantly modulated by anodal stimulation. These results demonstrate that MEG can be used to derive inferences on the cortical mechanisms of tDCS.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	Transcranial direct current stimulation; Neuromodulation; Magnetoencephalography; Brain oscillation; GABA; NMDA
Additional Information:	This is an open access article under the CC-BY-NC-ND license.
Publisher:	Elsevier
ISSN:	1053-8119
Date of First Compliant Deposit:	30 March 2016
Date of Acceptance:	14 December 2015
Last Modified:	02 May 2023 16:17
URI:	https://orca.cardiff.ac.uk/id/eprint/85498

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