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The Role of Human Dendritic Cells in HIV-1 Infection

Ahmed, Zahra, Kawamura, Tatsuyoshi, Shimada, Shinji and Piguet, Vincent 2015. The Role of Human Dendritic Cells in HIV-1 Infection. Journal of Investigative Dermatology 135 (5) , pp. 1225-1233. 10.1038/jid.2014.490

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Dendritic cells (DCs) and their subsets have multifaceted roles in the early stages of HIV-1 transmission and infection. DC studies have led to remarkable discoveries, including identification of restriction factors, cellular structures promoting viral transmission including the infectious synapse or the interplay of the C-type lectins, Langerin on Langerhans cells (LCs), and dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin on other DC subsets, limiting or facilitating HIV transmission to CD4+ T cells, respectively. LCs/DCs are also exposed to encountering HIV-1 and other sexually transmitted infections (herpes simplex virus-2, bacteria, fungi), which reprogram HIV-1 interaction with these cells. This review will summarize advances in the role of DCs during HIV-1 infection and discuss their potential involvement in the development of preventive strategies against HIV-1 and other sexually transmitted infections.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: Nature Publishing Group
ISSN: 0022-202X
Date of Acceptance: 27 September 2015
Last Modified: 05 Aug 2022 01:38

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