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Duration of depressive symptoms and mortality risk: The English Longitudinal Study of Ageing (ELSA)

White, James, Zaninotto, Paola, Walters, Kate, Kivimäki, Mika, Demakakos, Panayotes, Biddulp, Jane, Kumari, Meena, De Oliveira, Cesar, Gallacher, John and Batty, G. David 2016. Duration of depressive symptoms and mortality risk: The English Longitudinal Study of Ageing (ELSA). British Journal of Psychiatry 208 (4) , pp. 337-342. 10.1192/bjp.bp.114.155333

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Background The relationship between the duration of depressive symptoms and mortality remains poorly understood. Aims To examine whether the duration of depressive symptoms is associated with mortality risk. Method Data (n = 9560) came from the English Longitudinal Study of Ageing (ELSA). We assessed depressive symptom duration as the sum of examinations with an eight-item Center for Epidemiologic Studies Depression Scale score of ≥3; we ascertained mortality from linking our data to a national register. Results Relative to those participants who never reported symptoms, the age- and gender-adjusted hazard ratios for elevated depressive symptoms over 1, 2, 3 and 4 examinations were 1.41 (95% CI 1.15–1.74), 1.80 (95% CI 1.44–2.26), 1.97 (95% CI 1.57–2.47) and 2.48 (95% CI 1.90–3.23), respectively (P for trend <0.001). This graded association can be explained largely by differences in physical activity, cognitive function, functional impairments and physical illness. Conclusions In this cohort of older adults, the duration of depressive symptoms was associated with mortality in a dose–response manner.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Additional Information: This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND)licence. Published online January 21, 2016.
Publisher: Cambridge University Press
ISSN: 0007-1250
Funders: Medical Research Council
Date of First Compliant Deposit: 30 March 2016
Date of Acceptance: 20 February 2015
Last Modified: 23 Mar 2021 08:30

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