Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Perirhinal cortex lesions in rats: Novelty detection and sensitivity to interference

Albasser, Mathieu M., Olarte-Sánchez, Cristian M., Amin, Eman, Brown, Malcolm W., Kinnavane, Lisa and Aggleton, John Patrick ORCID: 2015. Perirhinal cortex lesions in rats: Novelty detection and sensitivity to interference. Behavioral Neuroscience 129 (3) , pp. 227-243. 10.1037/bne0000049

[thumbnail of orlarte-sanchez et al 2015.pdf]
PDF - Published Version
Available under License Creative Commons Attribution.

Download (1MB) | Preview


Rats with perirhinal cortex lesions received multiple object recognition trials within a continuous session to examine whether they show false memories. Experiment 1 focused on exploration patterns during the first object recognition test postsurgery, in which each trial contained 1 novel and 1 familiar object. The perirhinal cortex lesions reduced time spent exploring novel objects, but did not affect overall time spent exploring the test objects (novel plus familiar). Replications with subsequent cohorts of rats (Experiments 2, 3, 4.1) repeated this pattern of results. When all recognition memory data were combined (Experiments 1–4), giving totals of 44 perirhinal lesion rats and 40 surgical sham controls, the perirhinal cortex lesions caused a marginal reduction in total exploration time. That decrease in time with novel objects was often compensated by increased exploration of familiar objects. Experiment 4 also assessed the impact of proactive interference on recognition memory. Evidence emerged that prior object experience could additionally impair recognition performance in rats with perirhinal cortex lesions. Experiment 5 examined exploration levels when rats were just given pairs of novel objects to explore. Despite their perirhinal cortex lesions, exploration levels were comparable with those of control rats. While the results of Experiment 4 support the notion that perirhinal lesions can increase sensitivity to proactive interference, the overall findings question whether rats lacking a perirhinal cortex typically behave as if novel objects are familiar, that is, show false recognition. Rather, the rats retain a signal of novelty but struggle to discriminate the identity of that signal.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Psychology
Publisher: American Psychological Association
ISSN: 1939-0084
Funders: Wellcome Trust
Date of First Compliant Deposit: 21 April 2016
Date of Acceptance: 30 January 2015
Last Modified: 17 May 2024 18:47

Citation Data

Cited 22 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item


Downloads per month over past year

View more statistics