Overnight consolidation aids the transfer of statistical knowledge from the medial temporal lobe to the striatum

Durrant, Simon J., Cairney, Scott A. and Lewis, Penelope A. ORCID: https://orcid.org/0000-0003-1793-3520 2012. Overnight consolidation aids the transfer of statistical knowledge from the medial temporal lobe to the striatum. Cerebral Cortex -New York- Oxford University Press- 23 (10) , pp. 2467-2478. 10.1093/cercor/bhs244

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Abstract

Sleep is important for abstraction of the underlying principles (or gist) which bind together conceptually related stimuli, but little is known about the neural correlates of this process. Here, we investigate this issue using overnight sleep monitoring and functional magnetic resonance imaging (fMRI). Participants were exposed to a statistically structured sequence of auditory tones then tested immediately for recognition of short sequences which conformed to the learned statistical pattern. Subsequently, after consolidation over either 30min or 24h, they performed a delayed test session in which brain activity was monitored with fMRI. Behaviorally, there was greater improvement across 24h than across 30min, and this was predicted by the amount of slow wave sleep (SWS) obtained. Functionally, we observed weaker parahippocampal responses and stronger striatal responses after sleep. Like the behavioral result, these differences in functional response were predicted by the amount of SWS obtained. Furthermore, connectivity between striatum and parahippocampus was weaker after sleep, whereas connectivity between putamen and planum temporale was stronger. Taken together, these findings suggest that abstraction is associated with a gradual shift from the hippocampal to the striatal memory system and that this may be mediated by SWS.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Cardiff University Brain Research Imaging Centre (CUBRIC) Psychology
Subjects:	B Philosophy. Psychology. Religion > BF Psychology
Uncontrolled Keywords:	abstraction; consolidation; hippocampus; sleep; striatum
Publisher:	Oxford University Press
ISSN:	1047-3211
Last Modified:	31 Oct 2022 10:52
URI:	https://orca.cardiff.ac.uk/id/eprint/86554

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