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Association between cannabis and psychosis: epidemiologic evidence

Gage, Suzanne H., Hickman, Matthew and Zammit, Stanley ORCID: 2016. Association between cannabis and psychosis: epidemiologic evidence. Biological psychiatry 79 (7) , pp. 549-556. 10.1016/j.biopsych.2015.08.001

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Associations between cannabis use and psychotic outcomes are consistently reported, but establishing causality from observational designs can be problematic. We review the evidence from longitudinal studies that have examined this relationship and discuss the epidemiologic evidence for and against interpreting the findings as causal. We also review the evidence identifying groups at particularly high risk of developing psychosis from using cannabis. Overall, evidence from epidemiologic studies provides strong enough evidence to warrant a public health message that cannabis use can increase the risk of psychotic disorders. However, further studies are required to determine the magnitude of this effect, to determine the effect of different strains of cannabis on risk, and to identify high-risk groups particularly susceptible to the effects of cannabis on psychosis. We also discuss complementary epidemiologic methods that can help address these questions.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: Cannabis; Epidemiology; Longitudinal studies; Marijuana; Psychosis; Schizophrenia
Publisher: Elsevier
ISSN: 0006-3223
Date of Acceptance: 4 August 2015
Last Modified: 31 Oct 2022 10:56

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