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Remembering the time: a continuous clock

Lewis, Penelope A. ORCID: and Miall, R. Chris 2006. Remembering the time: a continuous clock. Trends in Cognitive Sciences 10 (9) , pp. 401-406. 10.1016/j.tics.2006.07.006

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The neural mechanisms for time measurement are currently a subject of much debate. This article argues that our brains can measure time using the same dorsolateral prefrontal cells that are known to be involved in working memory. Evidence for this is: (1) the dorsolateral prefrontal cortex is integral to both cognitive timing and working memory; (2) both behavioural processes are modulated by dopamine and disrupted by manipulation of dopaminergic projections to the dorsolateral prefrontal cortex; (3) the neurons in question ramp their activity in a temporally predictable way during both types of processing; and (4) this ramping activity is modulated by dopamine. The dual involvement of these prefrontal neurons in working memory and cognitive timing supports a view of the prefrontal cortex as a multipurpose processor recruited by a wide variety of tasks.

Item Type: Article
Status: Published
Schools: Psychology
Cardiff University Brain Research Imaging Centre (CUBRIC)
Subjects: B Philosophy. Psychology. Religion > BF Psychology
Publisher: Cell Press
ISSN: 1364-6613
Last Modified: 31 Oct 2022 10:56

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