Brain-derived neurotrophic factor (BDNF) overexpression in the forebrain results in learning and memory impairments

Cunha, C., Angelucci, A., D'Antoni, A., Dobrossy, M. D., Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578, Berardi, N. and Brambilla, Riccardo ORCID: https://orcid.org/0000-0003-3569-5706 2009. Brain-derived neurotrophic factor (BDNF) overexpression in the forebrain results in learning and memory impairments. Neurobiology of Disease 33 (3) , pp. 358-368. 10.1016/j.nbd.2008.11.004

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Abstract

In this study we analyzed the effect on behavior of a chronic exposure to brain-derived neurotrophic factor (BDNF), by analysing a mouse line overexpressing BDNF under the αCaMKII promoter, which drives the transgene expression exclusively to principal neurons of the forebrain. BDNF transgenic mice and their WT littermates were examined with a battery of behavioral tests, in order to evaluate motor coordination, learning, short and long-term memory formation. Our results demonstrate that chronic BDNF overexpression in the central nervous system (CNS) causes learning deficits and short-term memory impairments, both in spatial and instrumental learning tasks. This observation suggests that a widespread increase in BDNF in forebrain networks may result in adverse effects on learning and memory formation.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Publisher:	Elsevier
ISSN:	0969-9961
Last Modified:	02 Dec 2022 11:47
URI:	https://orca.cardiff.ac.uk/id/eprint/8712

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