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Antibiotic resistance among clinical Ureaplasma Isolates Recovered from Neonates in England and Wales between 2007 and 2013

Beeton, Michael L., Chalker, Victoria J., Jones, Lucy C., Maxwell, Nicola C. and Spiller, Owen Bradley 2016. Antibiotic resistance among clinical Ureaplasma Isolates Recovered from Neonates in England and Wales between 2007 and 2013. Antimicrobial Agents and Chemotherapy 60 (1) , pp. 52-56. 10.1128/AAC.00889-15

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Ureaplasma spp. are associated with numerous clinical sequelae with treatment options being limited due to patient and pathogen factors. This report examines the prevalence and mechanisms of antibiotic resistance among clinical strains isolated from 95 neonates, 32 women attending a sexual health clinic, and 3 patients under investigation for immunological disorders, between 2007 and 2013 in England and Wales. MICs were determined by using broth microdilution assays, and a subset of isolates were compared using the broth microdilution method and the Mycoplasma IST2 assay. The underlying molecular mechanisms for resistance were determined for all resistant isolates. Three isolates carried the tet(M) tetracycline resistance gene (2.3%; confidence interval [CI], 0.49 to 6.86%); two isolates were ciprofloxacin resistant (1.5%; CI, 0.07 to 5.79%) but sensitive to levofloxacin and moxifloxacin, while no resistance was seen to any macrolides tested. The MIC values for chloramphenicol were universally low (2 μg/ml), while inherently high-level MIC values for gentamicin were seen (44 to 66 μg/ml). The Mycoplasma IST2 assay identified a number of false positives for ciprofloxacin resistance, as the method does not conform to international testing guidelines. While antibiotic resistance among Ureaplasma isolates remains low, continued surveillance is essential to monitor trends and threats from importation of resistant clones.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Healthcare Sciences
Advanced Research Computing @ Cardiff (ARCCA)
Subjects: R Medicine > R Medicine (General)
Additional Information: Published online 12 October 2015 PDF uploaded in accordance with publisher's policies at (25.2.16)
Publisher: American Society for Microbiology
ISSN: 0066-4804
Funders: Plymouth Hospital Charities
Date of First Compliant Deposit: 30 March 2016
Date of Acceptance: 12 October 2015
Last Modified: 31 Mar 2020 16:30

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