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One ring to bring them all - the role of Ku in mammalian non-homologous end joining

Grundy, Gabrielle J., Moulding, Hayley, Caldecott, Keith W. and Rulten, Stuart L. 2014. One ring to bring them all - the role of Ku in mammalian non-homologous end joining. DNA Repair 17 , pp. 30-38. 10.1016/j.dnarep.2014.02.019

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The repair of DNA double strand breaks is essential for cell survival and several conserved pathways have evolved to ensure their rapid and efficient repair. The non-homologous end joining pathway is initiated when Ku binds to the DNA break site. Ku is an abundant nuclear heterodimer of Ku70 and Ku80 with a toroidal structure that allows the protein to slide over the broken DNA end and bind with high affinity. Once locked into placed, Ku acts as a tool-belt to recruit multiple interacting proteins, forming one or more non-homologous end joining complexes that act in a regulated manner to ensure efficient repair of DNA ends. Here we review the structure and functions of Ku and the proteins with which it interacts during non-homologous end joining.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: Q Science > QH Natural history > QH426 Genetics
Uncontrolled Keywords: Non-homologous end joining; Ku; Double-strand break; APLF; WRN
Publisher: Elsevier
ISSN: 1568-7864
Date of Acceptance: 25 February 2014
Last Modified: 31 Jan 2020 03:26

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