Functionalized α-helical peptide hydrogels for neural tissue engineering

Mehrban, Nazia, Zhu, Bangfu, Tamagnini, Francesco, Young, Fraser I. ORCID: https://orcid.org/0000-0003-0779-3835, Wasmuth, Alexandra, Hudson, Kieran L., Thomson, Andrew R., Birchall, Martin A., Randall, Andrew D., Song, Bing ORCID: https://orcid.org/0000-0001-9356-2333 and Woolfson, Derek N. 2015. Functionalized α-helical peptide hydrogels for neural tissue engineering. ACS Biomaterials Science and Engineering 1 (6) , pp. 431-439. 10.1021/acsbiomaterials.5b00051

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Abstract

Trauma to the central and peripheral nervous systems often lead to serious morbidity. Current surgical methods for repairing or replacing such damage have limitations. Tissue engineering offers a potential alternative. Here we show that functionalized α-helical-peptide hydrogels can be used to induce attachment, migration, proliferation and differentiation of murine embryonic neural stem cells (NSCs). Specifically, compared with undecorated gels, those functionalized with Arg-Gly-Asp-Ser (RGDS) peptides increase the proliferative activity of NSCs; promote their directional migration; induce differentiation, with increased expression of microtubule-associated protein-2, and a low expression of glial fibrillary acidic protein; and lead to the formation of larger neurospheres. Electrophysiological measurements from NSCs grown in RGDS-decorated gels indicate developmental progress toward mature neuron-like behavior. Our data indicate that these functional peptide hydrogels may go some way toward overcoming the limitations of current approaches to nerve-tissue repair.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Dentistry Neuroscience and Mental Health Research Institute (NMHRI)
Additional Information:	The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acsbiomaterials.5b00051.
Publisher:	American Chemical Society
ISSN:	2373-9878
Date of Acceptance:	28 April 2015
Last Modified:	01 Nov 2022 09:35
URI:	https://orca.cardiff.ac.uk/id/eprint/88468

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