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Rating scales for behavioural symptoms in Huntington's Disease: critique and recommendations

Mestre, Tiago A., van Duijn, Erik, Davis, Aileen M., Bachoud - Levi, Anne-Catherine, Busse, Monica ORCID:, Anderson, Karen E., Ferreira, Joaquim J., Mahlknecht, Philipp, Tumas, Vitor, Sampaio, Cristina, Goetz, Chris G., Cubo, Esther, Stebbins, Glen T. and Martinez-Martin, Pablo 2016. Rating scales for behavioural symptoms in Huntington's Disease: critique and recommendations. Movement Disorders 31 (10) , pp. 1466-1478. 10.1002/mds.26675

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Behavioral symptoms are an important feature of Huntington’s disease and contribute to impairment in quality of life. The Movement Disorder Society commissioned the assessment of the clinimetric properties of rating scales in Huntington’s disease in order to make recommendations regarding their use, following previously used standardized criteria. A systematic literature search was conducted to identify the scales used to assess behavioral symptoms in Huntington’s disease. For the purpose of this review, seven behavioral domains were deemed significant in Huntington’s disease: irritability, anxiety, depression, apathy, obsessive-compulsive behaviors, psychosis and suicidal ideation. We included a total of 27 behavioral rating scales, 19 of which were of a single behavioral domain, and the remaining 8 scales included multiple behavioral domains. Three rating scales were classified as “recommended” exclusively for screening purposes: the Irritability Scale for irritability, and the Beck Depression Inventory-II and the Hospital Anxiety and Depression Scale for depression. There were no “recommended” scales for other purposes such as diagnosis, severity or change in time or to treatment. The main challenges identified for assessment of behavioral symptoms in Huntington’s disease are the co-occurrence of multiple behavioural symptoms, the particular features of a behavioral symptom in Huntington’s disease, as well as the need to address stage- and disease-specific features, including cognitive impairment and lack of insight. The committee concluded that there is a need to further validate currently available behavioral rating scales in Huntington’s disease to address gaps in scale validation for specific behavioral domains and purpose of use.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Healthcare Sciences
Subjects: R Medicine > R Medicine (General)
Additional Information: Pdf uploaded in accordance with publisher's policy at (accessed 21/06/2016)
Publisher: Wiley-Blackwell
ISSN: 0885-3185
Date of First Compliant Deposit: 20 April 2016
Date of Acceptance: 14 April 2016
Last Modified: 02 Nov 2022 15:43

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