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Neonatal desensitization allows long-term survival of neural xenotransplants without immunosuppression

Kelly, Claire M, Precious, Sophie Victoria, Scherf, Caroline, Penketh, Richard, Amso, Nazar Najib ORCID:, Battersby, Alysia Agnes, Allen, Nicholas Denby ORCID:, Dunnett, Stephen Bruce ORCID: and Rosser, Anne Elizabeth ORCID: 2009. Neonatal desensitization allows long-term survival of neural xenotransplants without immunosuppression. Nature Methods 6 (4) , pp. 271-273. 10.1038/nmeth.1308

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Preclinical development of human cells for potential therapeutic application in neurodegenerative diseases requires that their long-term survival, stability and functional efficacy be studied in animal models of human disease. Here we describe a strategy for long-term immune protection of human fetal and stem cell–derived neural cells transplanted into the adult rat brain, by desensitizing the host rat to similar cells in the neonatal period, without the need for additional immunosuppression.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Neuroscience and Mental Health Research Institute (NMHRI)
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: Q Science > QR Microbiology > QR180 Immunology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher: Nature Publishing Group
ISSN: 1548-7091
Last Modified: 07 Feb 2023 02:17

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