Esters of some non-steroidal anti-inflammatory drugs with cinnamyl alcohol are potent lipoxygenase inhibitors with enhanced anti-inflammatory activity

Theodosis-Nobelos, Panagiotis, Kourti, Malamati, Tziona, Paraskevi, Kourounakis, Panos N. and Rekka, Eleni A. 2015. Esters of some non-steroidal anti-inflammatory drugs with cinnamyl alcohol are potent lipoxygenase inhibitors with enhanced anti-inflammatory activity. Biorganic & Medicinal Chemistry Letters 25 (22) , pp. 5028-5031. 10.1016/j.bmcl.2015.10.036

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Abstract

Novel esters of non steroidal anti-inflammatory drugs, α-lipoic acid and indol-3-acetic acid with cinnamyl alcohol were synthesised by a straightforward method and at high yields (60–98%). They reduced acute inflammation more than the parent acids and are potent inhibitors of soybean lipoxygenase. Selected structures decreased plasma lipidemic indices in Triton-induced hyperlipidemia to rats. Therefore, the synthesised compounds may add to the current knowledge about agents acting against various inflammatory disorders.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Uncontrolled Keywords:	Non steroidal anti-inflammatory drugs; Cinnamyl esters; Inflammation; Lipoxygenase inhibition; Dyslipidemia
Publisher:	Elsevier
ISSN:	0960-894X
Date of Acceptance:	13 October 2015
Last Modified:	09 Jun 2020 01:29
URI:	https://orca.cardiff.ac.uk/id/eprint/90348

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