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Post-meiotic transcription in Drosophila spermatogenesis

Barreau, Carine, Benson, Elizabeth, Gudmannsdottir, Elin, Newton, Fay and White-Cooper, Helen ORCID: 2008. Post-meiotic transcription in Drosophila spermatogenesis. Development 135 (11) , pp. 1897-1902. 10.1242/dev.021949

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Post-meiotic transcription was accepted to be essentially absent from Drosophila spermatogenesis. We identify 24 Drosophila genes whose mRNAs are most abundant in elongating spermatids. By single-cyst quantitative RT-PCR, we demonstrate post-meiotic transcription of these genes. We conclude that transcription stops in Drosophila late primary spermatocytes, then is reactivated by two pathways for a few loci just before histone-to-transition protein-to-protamine chromatin remodelling in spermiogenesis. These mRNAs localise to a small region at the distal elongating end of the spermatid bundles, thus they represent a new class of sub-cellularly localised mRNAs. Mutants for a post-meiotically transcribed gene (scotti), are male sterile, and show spermatid individualisation defects, indicating a function in late spermiogenesis.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QH Natural history > QH426 Genetics
Publisher: The Company of Biologists Ltd
ISSN: 0950-1991
Last Modified: 17 Oct 2022 10:45

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