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Detecting and discriminating novel objects: the impact of perirhinal cortex disconnection on hippocampal activity patterns

Kinnavane, Lisa, Amin, Eman, Olarte-Sanchez, Cristian and Aggleton, John Patrick ORCID: 2016. Detecting and discriminating novel objects: the impact of perirhinal cortex disconnection on hippocampal activity patterns. Hippocampus 26 (11) , pp. 1393-1413. 10.1002/hipo.22615

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Perirhinal cortex provides object-based information and novelty/familiarity information for the hippocampus. The necessity of these inputs was tested by comparing hippocampal c-fos expression in rats with or without perirhinal lesions. These rats either discriminated novel from familiar objects (Novel-Familiar) or explored pairs of novel objects (Novel-Novel). Despite impairing Novel-Familiar discriminations, the perirhinal lesions did not affect novelty detection, as measured by overall object exploration levels (Novel-Novel condition). The perirhinal lesions also largely spared a characteristic network of linked c-fos expression associated with novel stimuli (entorhinal cortex[RIGHTWARDS ARROW]CA3[RIGHTWARDS ARROW]distal CA1[RIGHTWARDS ARROW]proximal subiculum). The findings show: I) that perirhinal lesions preserve behavioral sensitivity to novelty, whilst still impairing the spontaneous ability to discriminate novel from familiar objects, II) that the distinctive patterns of hippocampal c-fos activity promoted by novel stimuli do not require perirhinal inputs, III) that entorhinal Fos counts (layers II and III) increase for novelty discriminations, IV) that hippocampal c-fos networks reflect proximal-distal connectivity differences, and V) that discriminating novelty creates different pathway interactions from merely detecting novelty, pointing to top-down effects that help guide object selection

Item Type: Article
Date Type: Publication
Status: Published
Schools: Psychology
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher: Wiley-Blackwell
ISSN: 1050-9631
Funders: Wellcome Trust, Wellcome Trust
Date of First Compliant Deposit: 28 June 2016
Date of Acceptance: 24 June 2016
Last Modified: 06 May 2023 06:52

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