Detecting and discriminating novel objects: the impact of perirhinal cortex disconnection on hippocampal activity patterns

Kinnavane, Lisa, Amin, Eman, Olarte-Sanchez, Cristian and Aggleton, John Patrick ORCID: https://orcid.org/0000-0002-5573-1308 2016. Detecting and discriminating novel objects: the impact of perirhinal cortex disconnection on hippocampal activity patterns. Hippocampus 26 (11) , pp. 1393-1413. 10.1002/hipo.22615

Preview

PDF - Published Version Available under License Creative Commons Attribution. Download (1MB) | Preview

Abstract

Perirhinal cortex provides object-based information and novelty/familiarity information for the hippocampus. The necessity of these inputs was tested by comparing hippocampal c-fos expression in rats with or without perirhinal lesions. These rats either discriminated novel from familiar objects (Novel-Familiar) or explored pairs of novel objects (Novel-Novel). Despite impairing Novel-Familiar discriminations, the perirhinal lesions did not affect novelty detection, as measured by overall object exploration levels (Novel-Novel condition). The perirhinal lesions also largely spared a characteristic network of linked c-fos expression associated with novel stimuli (entorhinal cortex[RIGHTWARDS ARROW]CA3[RIGHTWARDS ARROW]distal CA1[RIGHTWARDS ARROW]proximal subiculum). The findings show: I) that perirhinal lesions preserve behavioral sensitivity to novelty, whilst still impairing the spontaneous ability to discriminate novel from familiar objects, II) that the distinctive patterns of hippocampal c-fos activity promoted by novel stimuli do not require perirhinal inputs, III) that entorhinal Fos counts (layers II and III) increase for novelty discriminations, IV) that hippocampal c-fos networks reflect proximal-distal connectivity differences, and V) that discriminating novelty creates different pathway interactions from merely detecting novelty, pointing to top-down effects that help guide object selection

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher:	Wiley-Blackwell
ISSN:	1050-9631
Funders:	Wellcome Trust, Wellcome Trust
Date of First Compliant Deposit:	28 June 2016
Date of Acceptance:	24 June 2016
Last Modified:	06 May 2023 06:52
URI:	https://orca.cardiff.ac.uk/id/eprint/92175

Citation Data

Cited 22 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item