Wilbrecht, Linda, Holtmaat, Anthony, Wright, Nicholas Fraser, Fox, Kevin Dyson ORCID: https://orcid.org/0000-0002-2563-112X and Svoboda, Karel 2010. Structural plasticity underlies experience-dependent functional plasticity of cortical circuits. The Journal of Neuroscience 30 (14) , pp. 4927-4932. 10.1523/JNEUROSCI.6403-09.2010 |
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Abstract
The stabilization of new spines in the barrel cortex is enhanced after whisker trimming, but its relationship to experience-dependent plasticity is unclear. Here we show that in wild-type mice, whisker potentiation and spine stabilization are most pronounced for layer 5 neurons at the border between spared and deprived barrel columns. In homozygote αCaMKII-T286A mice, which lack experience-dependent potentiation of responses to spared whiskers, there is no increase in new spine stabilization at the border between barrel columns after whisker trimming. Our data provide a causal link between new spine synapses and plasticity of adult cortical circuits and suggest that αCaMKII autophosphorylation plays a role in the stabilization but not formation of new spines.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Psychology Biosciences |
Subjects: | R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
Additional Information: | Pdf uploaded in accordance with publisher's policy at http://www.jneurosci.org/site/misc/ifa_policies.xhtml#copyright (accessed 26/02/2014). |
Publisher: | Society for Neuroscience |
ISSN: | 0270-6474 |
Funders: | MRC |
Date of First Compliant Deposit: | 30 March 2016 |
Last Modified: | 11 May 2023 16:24 |
URI: | https://orca.cardiff.ac.uk/id/eprint/9283 |
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