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Calcium and ATP control multiple vital functions

Petersen, Ole and Verkhratsky, Alexei 2016. Calcium and ATP control multiple vital functions. Philosophical Transactions of the Royal Society B: Biological Sciences 371 (1700) , p. 20150418. 10.1098/rstb.2015.0418

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Life on Planet Earth, as we know it, revolves around adenosine triphosphate (ATP) as a universal energy storing molecule. The metabolism of ATP requires a low cytosolic Ca2þ concentration, and hence tethers these two molecules together. The exceedingly low cytosolic Ca2þ concentration (which in all life forms is kept around 50–100 nM) forms the basis for a universal intracellular signalling system in which Ca2þ acts as a second messenger. Maintenance of transmembrane Ca2þ gradients, in turn, requires ATP-dependent Ca2þ transport, thus further emphasizing the inseparable links between these two substances. Ca2þ signalling controls the most fundamental processes in the living organism, from heartbeat and neurotransmission to cell energetics and secretion. The versatility and plasticity of Ca2þ signalling relies on cell specific Ca2þ signalling toolkits, remodelling of which underlies adaptive cellular responses. Alterations of these Ca2þ signalling toolkits lead to aberrant Ca2þ signalling which is fundamental for the pathophysiology of numerous diseases from acute pancreatitis to neurodegeneration. This paper introduces a theme issue on this topic, which arose from a Royal Society Theo Murphy scientific meeting held in March 2016. This article is part of the themed issue ‘Evolution brings Ca2þ and ATP together to control life and death’.

Item Type: Article
Date Type: Acceptance
Status: Published
Schools: Biosciences
Publisher: Royal Society Publishing
ISSN: 09628436
Date of First Compliant Deposit: 9 August 2016
Date of Acceptance: 10 May 2016
Last Modified: 29 Jun 2017 13:24

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