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Evaluation of geometrical effects of microneedles on skin penetration by CT scan and finite element analysis

Loizidou, Eriketi Z., Inoue, Nicholas T., Ashton-Barnett, Johnny, Barrow, David A. and Allender, Christopher J. 2016. Evaluation of geometrical effects of microneedles on skin penetration by CT scan and finite element analysis. European Journal of Pharmaceutics and Biopharmaceutics 107 , pp. 1-6. 10.1016/j.ejpb.2016.06.023

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Computerized tomography scan (CT scan) imaging and finite element analysis were employed to investigate how the geometric composition of microneedles affects their mechanical strength and penetration characteristics. Simulations of microneedle arrays, comprising triangular, square and hexagonal microneedle base, revealed a linear dependence of the mechanical strength to the number of vertices in the polygon base. A laser-enabled, micromoulding technique was then used to fabricate 3 × 3 microneedle arrays, each individual microneedle having triangular, square or hexagonal base geometries. Their penetration characteristics into ex-vivo porcine skin, were investigated for the first time by CT scan imaging. This revealed greater penetration depths for the triangular and square-based microneedles, demonstrating CT scan as a powerful and reliable technique for studying microneedle skin penetration.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Engineering
Subjects: T Technology > TJ Mechanical engineering and machinery
Uncontrolled Keywords: Microneedles; Microfabrication; Laser ablation; Computerized tomography; Skin penetration; Structural mechanics simulations; COMSOL
Publisher: Elsevier
ISSN: 0939-6411
Date of Acceptance: 29 June 2016
Last Modified: 21 Oct 2019 14:56

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