Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Patterns of bruising in preschool children with inherited bleeding disorders: a longitudinal study

Collins, Peter ORCID:, Hamilton, Melinda, Dunstan, Frank David John ORCID:, Maguire, Sabine Ann, Nuttall, Diane ORCID:, Liesner, Ri, Thomas, Angela E., Hanley, John, Chalmers, Elizabeth, Blanchette, Victor and Kemp, Alison Mary ORCID: 2016. Patterns of bruising in preschool children with inherited bleeding disorders: a longitudinal study. Archives of Disease in Childhood , pp. 401-413. 10.1136/archdischild-2015-310196

[thumbnail of archdischild-2015-310196.full.pdf]
Available under License Creative Commons Attribution.

Download (511kB) | Preview
License URL:
License Start date: 1 January 2015


Objective The extent that inherited bleeding disorders affect; number, size and location of bruises in young children <6 years. Design Prospective, longitudinal, observational study. Setting Community. Patients 105 children with bleeding disorders, were compared with 328 without a bleeding disorder and classified by mobility: premobile (non-rolling/rolling over/ sitting), early mobile (crawling/cruising) and walking and by disease severity: severe bleeding disorder factor VIII/IX/XI <1 IU/dL or type 3 von Willebrand disease. Interventions Number, size and location of bruises recorded in each child weekly for up to 12 weeks. Outcomes The interventions were compared between children with severe and mild/moderate bleeding disorders and those without bleeding disorders. Multiple collections for individual children were analysed by multilevel modelling. Results Children with bleeding disorders had more and larger bruises, especially when premobile. Compared with premobile children without a bleeding disorder; the modelled ratio of means (95% CI) for number of bruises/ collection was 31.82 (8.39 to 65.42) for severe bleeding disorders and 5.15 (1.23 to 11.17) for mild/moderate, and was 1.81 (1.13 to 2.23) for size of bruises. Children with bleeding disorders rarely had bruises on the ears, neck, cheeks, eyes or genitalia. Conclusions Children with bleeding disorder have more and larger bruises at all developmental stages. The differences were greatest in premobile children. In this age group for children with unexplained bruising, it is essential that coagulation studies are done early to avoid the erroneous diagnosis of physical abuse when the child actually has a serious bleeding disorder, however a blood test compatible with a mild/moderate bleeding disorder cannot be assumed to be the cause of bruising.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Medicine
Subjects: R Medicine > RJ Pediatrics
Publisher: BMJ Publishing Group
ISSN: 0003-9888
Funders: Medical Research Council
Date of First Compliant Deposit: 11 August 2016
Date of Acceptance: 7 June 2016
Last Modified: 13 Jul 2023 03:44

Citation Data

Cited 11 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item


Downloads per month over past year

View more statistics