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Functional brain networks underlying latent inhibition of conditioned disgust in rats

Gasalla Canto, Patricia, Begega, Azucena, Soto, Alberto, Dwyer, Dominic M. ORCID: and López, Matías 2016. Functional brain networks underlying latent inhibition of conditioned disgust in rats. Behavioural Brain Research 315 , pp. 36-44. 10.1016/j.bbr.2016.07.051

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The present experiment examined the neuronal networks involved in the latent inhibition of conditioned disgust by measuring brain oxidative metabolism. Rats were given nonreinforced intraoral (IO) exposure to saccharin (exposed groups) or water (non-exposed groups) followed by a conditioning trial in which the animals received an infusion of saccharin paired (or unpaired) with LiCl. On testing, taste reactivity responses displayed by the rats during the infusion of the saccharin were examined. Behavioral data showed that preexposure to saccharin attenuated the development of LiCl-induced conditioned disgust reactions, indicating that the effects of taste aversion on hedonic taste reactivity had been reduced. With respect to cumulative oxidative metabolic activity across the whole study period, the parabrachial nucleus was the only single region examined which showed differential activity between groups which received saccharin-LiCl pairings with and without prior non-reinforced saccharin exposure, suggesting a key role in the effects of latent inhibition of taste aversion learning. In addition, many functional connections between brain regions were revealed through correlational analysis of metabolic activity, in particular an accumbens-amygdala interaction that may be involved in both positive and negative hedonic responses.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Psychology
Subjects: B Philosophy. Psychology. Religion > BF Psychology
Publisher: Elsevier
ISSN: 0166-4328
Date of First Compliant Deposit: 22 August 2016
Date of Acceptance: 30 July 2016
Last Modified: 07 Nov 2023 01:06

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