Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

The implications of the shared genetics of psychiatric disorders

O'Donovan, Michael Conlon ORCID: and Owen, Michael John ORCID: 2016. The implications of the shared genetics of psychiatric disorders. Nature Medicine 22 , pp. 1214-1219. 10.1038/nm.4196

[thumbnail of ODonovan_final_1473281170_81.pdf]
PDF - Accepted Post-Print Version
Download (401kB) | Preview


Recent genomic studies have revealed the highly polygenic nature of psychiatric disorders, including schizophrenia, bipolar disorder and major depressive disorder. Many of the individual genetic associations are shared across multiple disorders in a way that points to extensive biological pleiotropy and further challenges the biological validity of existing diagnostic approaches. Here we argue that the existence of risk alleles specific to a single diagnostic category is unlikely. We also highlight some of the important clinical repercussions of pleiotropy

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: Autism spectrum disorders Disease genetics Psychiatric disorders
Publisher: Nature Publishing Group
ISSN: 1078-8956
Date of First Compliant Deposit: 26 September 2016
Date of Acceptance: 8 September 2016
Last Modified: 07 Nov 2023 00:08

Citation Data

Cited 89 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item


Downloads per month over past year

View more statistics