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Sudden death in epilepsy: insights from the last 25 years

Jones, Lliwen and Thomas, Rhys Huw 2017. Sudden death in epilepsy: insights from the last 25 years. Seizure - European Journal of Epilepsy 44 , pp. 232-236. 10.1016/j.seizure.2016.10.002

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Sudden unexpected death in epilepsy (SUDEP) is the leading cause of mortality in patients with refractory epilepsy, and as such has been a major research focus over the last 25 years. The earliest SUDEP research papers were published in Seizure, as have scores of SUDEP papers since. In this review we discuss the efforts to try and describe the pathophysiological basis of SUDEP, the drive to discover the clinical risk factors that increase the likelihood of SUDEP, and the motivation to increase awareness of SUDEP. These three areas are the prime factors that, when answered, will allow us to better mitigate against SUDEP and help individuals monitor their personal risk. The field has benefited from strong definitions, multinational collaboration, the use of cutting edge genetic analysis, and ensuring that bereaved families are able to take part in research when this is appropriate. Clearly there is much that we do not know and yet, has any area of epilepsy research come so far in the last 25 years?

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: Epilepsy, SUDEP, death
Publisher: Elsevier
ISSN: 1059-1311
Date of First Compliant Deposit: 24 October 2016
Date of Acceptance: 3 October 2016
Last Modified: 13 Mar 2020 17:15

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