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The use of structural modelling to infer structure and function in biocontrol agents

Berry, Colin ORCID: and Board, Jason 2017. The use of structural modelling to infer structure and function in biocontrol agents. Journal of Invertebrate Pathology 142 , pp. 23-26. 10.1016/j.jip.2016.07.014

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Homology modelling can provide important insights into the structures of proteins when a related protein structure has already been solved. However, for many proteins, including a number of invertebrate-active toxins and accessory proteins, no such templates exist. In these cases, techniques of ab initio, template-independent modelling can be employed to generate models that may give insight into structure and function. In this overview, examples of both the problems and the potential benefits of ab initio techniques are illustrated. Consistent modelling results may indicate useful approximations to actual protein structures and can thus allow the generation of hypotheses regarding activity that can be tested experimentally.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Advanced Research Computing @ Cardiff (ARCCA)
Subjects: Q Science > Q Science (General)
Uncontrolled Keywords: Insecticidal toxins; Bacillus thuringiensis; Structural modelling; P20; PirB
Publisher: Elsevier
ISSN: 0022-2011
Date of First Compliant Deposit: 8 November 2016
Date of Acceptance: 28 July 2016
Last Modified: 07 Nov 2023 04:57

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