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Adverse childhood life events and postpartum psychosis in bipolar disorder

Perry, A., Gordon-Smith, K., Di Florio, Arianna ORCID:, Forty, Elizabeth, Craddock, Nicholas John ORCID:, Jones, L. and Jones, Ian Richard ORCID: 2016. Adverse childhood life events and postpartum psychosis in bipolar disorder. Journal of affective disorders 205 , pp. 69-72. 10.1016/j.jad.2016.06.061

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Background Women with bipolar disorder are at increased risk of postpartum psychosis. Adverse childhood life events have been associated with depression in the postpartum period, but have been little studied in relation to postpartum psychosis. In this study we investigated whether adverse childhood life events are associated with postpartum psychosis in a large sample of women with bipolar I disorder. Methods Participants were 432 parous women with DSM-IV bipolar I disorder recruited into the Bipolar Disorder Research Network ( Diagnoses and lifetime psychopathology, including perinatal episodes, were obtained via a semi-structured interview (Schedules for Clinical Assessment in Neuropsychiatry; Wing et al., 1990) and case-notes. Adverse childhood life events were assessed via self-report and case-notes, and compared between women with postpartum psychosis (n=208) and those without a lifetime history of perinatal mood episodes (n=224). Results There was no significant difference in the rate of any adverse childhood life event, including childhood sexual abuse, or in the total number of adverse childhood life events between women who experienced postpartum psychosis and those without a lifetime history of perinatal mood episodes, even after controlling for demographic and clinical differences between the groups. Limitations Adverse childhood life events were assessed in adulthood and therefore may be subject to recall errors. Conclusions We found no evidence for an association between adverse childhood life events and the occurrence of postpartum psychosis. Our data suggest that, unlike postpartum depression, childhood adversity does not play a significant role in the triggering of postpartum psychosis in women with bipolar disorder.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: R Medicine > R Medicine (General)
R Medicine > RG Gynecology and obstetrics
Publisher: Elsevier
ISSN: 0165-0327
Date of First Compliant Deposit: 10 November 2016
Date of Acceptance: 26 June 2016
Last Modified: 18 Nov 2023 09:19

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