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Do cortical plasticity mechanisms differ between males and females?

Dachtler, James and Fox, Kevin Dyson ORCID: 2017. Do cortical plasticity mechanisms differ between males and females? Journal of Neuroscience Research 95 (1-2) , pp. 518-526. 10.1002/jnr.23850

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The difference between male and female behavior and male and female susceptibility to a number of neuropsychiatric conditions is not controversial. From a biological perspective, one might expect to see at least some of these differences underpinned by identifiable physical differences in the brain. This Mini-Review focuses on evidence that plasticity mechanisms differ between males and females and ask at what scale of organization the differences might exist, at the systems level, the circuits level, or the synaptic level. Emerging evidence suggests that plasticity differences may extend to the scale of synaptic mechanisms. In particular, the CaMKK, NOS1 and estrogen receptor pathways show sexual dimorphisms with implications for plasticity in the hippocampus and cerebral cortex.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Wiley-Blackwell
ISSN: 0360-4012
Funders: MRC
Date of First Compliant Deposit: 6 January 2017
Date of Acceptance: 6 July 2016
Last Modified: 04 May 2023 04:38

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