NHERF1 regulates the progression of colorectal cancer through the interplay with VEGFR2 pathway

Gu, Yanan, Yu, Hefen, Hao, Chengcheng, Martin, Tracey Amanda ORCID: https://orcid.org/0000-0003-2690-4908, Hargest, Rachel ORCID: https://orcid.org/0000-0001-9830-3832, He, Junqi, Cheng, Shan and Jiang, Wen Guo ORCID: https://orcid.org/0000-0002-3283-1111 2017. NHERF1 regulates the progression of colorectal cancer through the interplay with VEGFR2 pathway. Oncotarget 8 (5) , pp. 7753-7765. 10.18632/oncotarget.13949

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Abstract

The oncogenic role of ectopic expression of Na+/H+ exchanger regulatory factor 1 (NHERF1) was recently suggested in colorectal cancer, where it was implicated in playing a role in the tumor hypoxia microenvironment. Here we showed that a high level expression of NHERF1 was found in colorectal cancer tissues and that the expression of NHERF1 was positively correlated with VEGFR2 expression. The prognostic value of VEGFR2 expression in colorectal cancer relied on the expression of NHERF1. The up-regulation of NHERF1 induced by the exposure to hypoxia in colon cancer cells depended on the activation of VEGFR2 signaling. NHERF1 in turn inhibited the activation of VEGFR2 signaling which could be regulated by the interaction between NHERF1 and VEGFR2, resulting in the reduction of migration and invasion of colon cancer cells. These results suggest a dynamic interplay between NHERF1 and VEGFR2 signaling in colorectal cancer, which could explain the contribution of NHERF1 to the regulation of tumor cell responses to the hypoxia microenvironment.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Publisher:	Impact Journals
ISSN:	1949-2553
Funders:	National Natural Science Foundation of the People's Republic of China, Albert Hung Foundation, Cancer Research Wales
Date of First Compliant Deposit:	8 December 2016
Date of Acceptance:	1 December 2016
Last Modified:	05 May 2023 09:15
URI:	https://orca.cardiff.ac.uk/id/eprint/96720

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