Schuur, Boelo, Floure, Joelle, Hallett, Andrew Jon, Winkelman, Jozef G. M., de Vries, Johannes and Heeres, Hero J. 2008. Continuous chiral separation of amino acid derivatives by enantioselective liquid-liquid extraction in centrifugal contactor separators. Organic Process Research and Development 12 (5) , pp. 950-955. 10.1021/op800074w |
Abstract
The continuous enantioselective liquid−liquid extraction of aqueous 3,5-dinitrobenzoyl-d,l-leucine (DNB-d,l-leu) by a cinchona alkaloid extractant (CA) in 1,2-dichloroethane using a centrifugal contact separator (CCS) was studied at 294 K. Typical concentrations were in the order of 1 mM for both DNB-d,l-leu and CA. The best results were found at a pH of 6, with 61% yield for DNB-l-leu and an enantiomeric excess of 34%. Back-extraction studies at different pH values showed that the host can be recovered efficiently in a single CCS, provided that pH > 9. Experimental studies indicate that the CCS behaves as an equilibrium extraction stage, even at total throughputs exceeding 50% of the equipment capacity (1.9 L min−1). A previously developed equilibrium stage extraction model was successfully applied to describe the data for both the extraction and the back-extraction experiments
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Chemistry |
Subjects: | Q Science > QD Chemistry |
Publisher: | ACS |
ISSN: | 1083-6160 |
Last Modified: | 19 Mar 2016 22:15 |
URI: | https://orca.cardiff.ac.uk/id/eprint/9687 |
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