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Clinical improvements following bilateral anterior capsulotomy in treatment-resistant depression

Subramanian, Leena, Bracht, Tobias, Jenkins, P., Choppin, S., Linden, David Edmund Johannes ORCID:, Phillips, G. and Simpson, B. A. 2016. Clinical improvements following bilateral anterior capsulotomy in treatment-resistant depression. Psychological Medicine 47 (6) , pp. 1097-1106. 10.1017/S0033291716003159

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The purpose of this study was to evaluate a programme of lesion surgery carried out on patients with treatment-resistant depression (TRD). This was a retrospective study looking at clinical and psychometric data from 45 patients with TRD who had undergone bilateral stereotactic anterior capsulotomy surgery over a period of 15 years, with the approval of the Mental Health Act Commission (37 with unipolar depression and eight with bipolar disorder). The Beck Depression Inventory (BDI) before and after surgery was used as the primary outcome measure. The Montgomery–Asberg Depression Rating Scale was administered and cognitive aspects of executive and memory functions were also examined. We carried out a paired-samples t test on the outcome measures to determine any statistically significant change in the group as a consequence of surgery. Patients improved on the clinical measure of depression after surgery by −21.20 points on the BDI with a 52% change. There were no significant cognitive changes post-surgery. Six patients were followed up in 2013 by phone interview and reported a generally positive experience. No major surgical complications occurred. With the limitations of an uncontrolled, observational study, our data suggest that capsulotomy can be an effective treatment for otherwise TRD. Performance on neuropsychological tests did not deteriorate.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Cardiff University Brain Research Imaging Centre (CUBRIC)
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: Anterior capsulotomy depression mood disorder stereotactic neurosurgery treatment resistance
Publisher: Cambridge University Press
ISSN: 0033-2917
Date of First Compliant Deposit: 19 December 2016
Date of Acceptance: 8 November 2016
Last Modified: 07 Nov 2023 05:40

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