Holst, Benjamin, Szakmany, Tamas, Raby, Anne-Catherine, Hamlyn, Vincent, Durno, Kimberley, Hall, Judith Elizabeth and Labéta, Mario O.
2017.
Soluble toll-like receptor 2 is a biomarker for sepsis in critically ill patients with multi-organ failure within 12 h of ICU admission.
Intensive Care Medicine Experimental
5
(1)
10.1186/s40635-016-0116-z
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Official URL: http://dx.doi.org/10.1186/s40635-016-0116-z
Abstract
Soluble TLR2 levels are elevated in infective and inflammatory conditions, but its diagnostic value with sepsis-induced multi-organ failure has not been evaluated. 37 patients with a diagnosis of severe sepsis/septic shock (sepsis) and 27 patients with organ failure without infection (SIRS) were studied. Median (IQR) plasma sTLR2 levels were 2.7 ng/ml (1.4–6.1) in sepsis and 0.6 ng/ml (0.4–0.9) in SIRS p < 0.001. sTLR2 showed good diagnostic value for sepsis at cut-off of 1.0 ng/ml, AUC:0.959. We report the ability of sTLR2 levels to discriminate between sepsis and SIRS within 12 h of ICU admission in patients with multi-organ failure.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Medicine |
Subjects: | R Medicine > R Medicine (General) |
Publisher: | Springer |
ISSN: | 2197-425X |
Funders: | Wellcome Trust |
Date of First Compliant Deposit: | 13 January 2017 |
Date of Acceptance: | 29 December 2016 |
Last Modified: | 21 Mar 2022 11:20 |
URI: | https://orca.cardiff.ac.uk/id/eprint/97414 |
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