Holst, Benjamin, Szakmany, Tamas  ORCID: https://orcid.org/0000-0003-3632-8844, Raby, Anne-Catherine ORCID: https://orcid.org/0000-0002-5354-5835, Hamlyn, Vincent, Durno, Kimberley, Hall, Judith Elizabeth ORCID: https://orcid.org/0000-0002-6770-7372 and Labéta, Mario O.
2017.
Soluble toll-like receptor 2 is a biomarker for sepsis in critically ill patients with multi-organ failure within 12 h of ICU admission.
Intensive Care Medicine Experimental
5
(1)
10.1186/s40635-016-0116-z
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Abstract
Soluble TLR2 levels are elevated in infective and inflammatory conditions, but its diagnostic value with sepsis-induced multi-organ failure has not been evaluated. 37 patients with a diagnosis of severe sepsis/septic shock (sepsis) and 27 patients with organ failure without infection (SIRS) were studied. Median (IQR) plasma sTLR2 levels were 2.7 ng/ml (1.4–6.1) in sepsis and 0.6 ng/ml (0.4–0.9) in SIRS p < 0.001. sTLR2 showed good diagnostic value for sepsis at cut-off of 1.0 ng/ml, AUC:0.959. We report the ability of sTLR2 levels to discriminate between sepsis and SIRS within 12 h of ICU admission in patients with multi-organ failure.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Medicine |
| Subjects: | R Medicine > R Medicine (General) |
| Publisher: | Springer |
| ISSN: | 2197-425X |
| Funders: | Wellcome Trust |
| Date of First Compliant Deposit: | 13 January 2017 |
| Date of Acceptance: | 29 December 2016 |
| Last Modified: | 23 May 2024 01:15 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/97414 |
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