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Time-course and mechanisms of homeostatic plasticity in layers 2/3 and 5 of the barrel cortex

Glazewski, Stanislaw, Greenhill, Stuart ORCID: and Fox, Kevin ORCID: 2017. Time-course and mechanisms of homeostatic plasticity in layers 2/3 and 5 of the barrel cortex. Philosophical Transactions B: Biological Sciences 372 (1715) , 20160150. 10.1098/rstb.2016.0150

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Recent studies have shown that ocular dominance plasticity in layer 2/3 of the visual cortex exhibits a form of homeostatic plasticity that is related to synaptic scaling and depends on TNFα. In this study, we tested whether a similar form of plasticity was present in layer 2/3 of the barrel cortex and, therefore, whether the mechanism was likely to be a general property of cortical neurons. We found that whisker deprivation could induce homeostatic plasticity in layer 2/3 of barrel cortex, but not in a mouse strain lacking synaptic scaling. The time-course of homeostatic plasticity in layer 2/3 was similar to that of L5 regular spiking (RS) neurons (L5RS), but slower than that of L5 intrinsic bursting (IB) neurons (L5IB). In layer 5, the strength of evoked whisker responses and ex vivo miniature excitatory post-synaptic currents (mEPSCs) amplitudes showed an identical time-course for homeostatic plasticity, implying that plasticity at excitatory synapses contacting layer 5 neurons is sufficient to explain the changes in evoked responses. Spontaneous firing rate also showed homeostatic behaviour for L5IB cells, but was absent for L5RS cells over the time-course studied. Spontaneous firing rate homeostasis was found to be independent of evoked response homeostasis suggesting that the two depend on different mechanisms. This article is part of the themed issue ‘Integrating Hebbian and homeostatic plasticity’.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > Q Science (General)
Uncontrolled Keywords: synapse; LTP; experience-dependent; LTD; synaptic scaling; sensory cortex
Additional Information: Published by the Royal Society under the terms of the Creative Commons Attribution License, which permits unrestricted use, provided the original author and source are credited.
Publisher: Royal Society, The
ISSN: 0962-8436
Date of First Compliant Deposit: 25 January 2017
Date of Acceptance: 3 October 2016
Last Modified: 07 May 2023 23:46

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