Ultra-high-field fMRI reveals a role for the subiculum in scene perceptual discrimination

Hodgetts, Carl J. ORCID: https://orcid.org/0000-0002-0339-2447, Voets, Natalie L., Thomas, Adam G., Clare, Stuart, Lawrence, Andrew D. ORCID: https://orcid.org/0000-0001-6705-2110 and Graham, Kim S. ORCID: https://orcid.org/0000-0002-1512-7667 2017. Ultra-high-field fMRI reveals a role for the subiculum in scene perceptual discrimination. Journal of Neuroscience 37 (12) , pp. 3150-3159. 10.1523/JNEUROSCI.3225-16.2017

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Abstract

Recent “representational” accounts suggest a key role for the hippocampus in complex scene perception. Due to limitations in scanner field strength, however, the functional neuroanatomy of hippocampal-dependent scene perception is unknown. Here, we applied 7 T high-resolution functional magnetic resonance imaging (fMRI) alongside a perceptual oddity task, modified from nonhuman primate studies. This task requires subjects to discriminate highly similar scenes, faces, or objects from multiple viewpoints, and has revealed selective impairments during scene discrimination following hippocampal lesions. Region-of-interest analyses identified a preferential response in the subiculum subfield of the hippocampus during scene, but not face or object, discriminations. Notably, this effect was in the anteromedial subiculum and was not modulated by whether scenes were subsequently remembered or forgotten. These results highlight the value of ultra-high-field fMRI in generating more refined, anatomically informed, functional accounts of hippocampal contributions to cognition, and a unique role for the human subiculum in discrimination of complex scenes from different viewpoints.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology Cardiff University Brain Research Imaging Centre (CUBRIC)
Subjects:	R Medicine > R Medicine (General)
Additional Information:	This is an open-access article distributed under the terms of the Creative Commons Attribution License.
Publisher:	Society for Neuroscience
ISSN:	1529-2401
Funders:	MRC, Wellcome Trust
Date of First Compliant Deposit:	1 February 2017
Date of Acceptance:	19 January 2017
Last Modified:	05 May 2023 07:03
URI:	https://orca.cardiff.ac.uk/id/eprint/97952

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