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`NMR Crystallization': in-situ NMR techniques for time-resolved monitoring of crystallization processes

Harris, Kenneth D.M. ORCID:, Hughes, Colan, Williams, Philip Andrew and Edwards-Gau, Gregory R. 2017. `NMR Crystallization': in-situ NMR techniques for time-resolved monitoring of crystallization processes. Acta Crystallographica Section C Structural Chemistry C73 (3) , pp. 137-148. 10.1107/S2053229616019811

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Solid-state NMR spectroscopy is a well-established and versatile technique for studying structural and dynamic properties of solids, and there is considerable potential to exploit the power and versatility of solid-state NMR for in-situ studies of chemical processes. However, a number of technical challenges are associated with adapting this technique for in-situ studies, depending on the process of interest. Recently, an in-situ solid-state NMR strategy for monitoring the evolution of crystallization processes has been developed and has proven to be a promising approach for identifying the sequence of distinct solid forms present as a function of time during crystallization from solution, and for the discovery of new polymorphs. The latest development of this technique, called “CLASSIC” NMR, allows simultaneous measurement of both liquid-state and solid-state NMR spectra as a function of time, thus yielding complementary information on the evolution of both the liquid phase and the solid phase during crystallization from solution. This article gives an overview of the range of NMR strategies that are currently available for in-situ studies of crystallization processes, with examples of applications that highlight the potential of these strategies to deepen our understanding of crystallization phenomena.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Subjects: Q Science > QD Chemistry
Uncontrolled Keywords: NMR crystallography; in-situ NMR; CLASSIC NMR; time-resolved; crystallization processes.
Publisher: Wiley
ISSN: 2053-2296
Funders: EPSRC and BBSRC
Date of First Compliant Deposit: 7 February 2017
Date of Acceptance: 12 December 2016
Last Modified: 08 Nov 2023 04:40

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