Sleep loss as a trigger of mood episodes in bipolar disorder: individual differences based on diagnostic subtype and gender

Lewis, Katie, Gordon-Smith, Katherine, Forty, Liz, Di Florio, Arianna ORCID: https://orcid.org/0000-0003-0338-2748, Craddock, Nick ORCID: https://orcid.org/0000-0003-2171-0610, Jones, Lisa ORCID: https://orcid.org/0000-0001-5821-5889 and Jones, Ian ORCID: https://orcid.org/0000-0001-5821-5889 2017. Sleep loss as a trigger of mood episodes in bipolar disorder: individual differences based on diagnostic subtype and gender. British Journal of Psychiatry 211 (3) , pp. 169-174. 10.1192/bjp.bp.117.202259

Preview

PDF - Published Version Available under License Creative Commons Attribution. Download (634kB) | Preview

Abstract

Background: Sleep loss may trigger mood episodes in people with bipolar disorder (BD) but individual differences could influence vulnerability to this trigger. Aims: To determine whether bipolar subtype (BD-I or BD-II) and gender were associated with vulnerability to the sleep loss trigger. Method: During a semi-structured interview, 3140 individuals (68% female) with BD (66% BD-I) reported whether sleep loss had triggered episodes of high or low mood. DSM-IV diagnosis of bipolar subtype was derived from case note and interview data. Results: Sleep loss triggering episodes of high mood was associated with female gender (OR = 1.43, 95% CI 1.17-1.75, P <.001) and BD-I subtype (OR = 2.81, 95% CI 2.26-3.50, P <.001). Analyses on sleep loss triggering low mood were not significant following adjustment for confounders. Conclusions: Gender and bipolar subtype may increase vulnerability to high mood following sleep deprivation. This should be considered in situations where patients encounter sleep disruption, such as shift-work and international travel.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects:	R Medicine > R Medicine (General)
Publisher:	Cambridge University Press
ISSN:	0007-1250
Funders:	Arthritis Research UK
Date of First Compliant Deposit:	19 April 2017
Date of Acceptance:	5 April 2017
Last Modified:	20 Oct 2023 06:18
URI:	https://orca.cardiff.ac.uk/id/eprint/99949

Citation Data

Cited 79 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item