ORCA
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Up a levelNumber of items: 8.
McGuigan, Christopher  ORCID: https://orcid.org/0000-0001-8409-710X, Madela, Karolina, Aljarah, Mohamed, Bourdin, Claire, Arrica, Maria, Barrett, Emma, Jones, Sarah Louise, Kolykhalov, Alexander, Bleiman, Blair, Bryant, K. Dawn, Ganguly, Babita, Gorovits, Elena, Henson, Geoffrey, Hunley, Damound, Hutchins, Jeff, Muhammad, Jerry, Obikhod, Aleksandr, Patti, Joseph, Walters, C. Robin, Wang, Jin, Vernachio, John, Ramamurty, Changalvala V. S., Battina, Srinivas K. and Chamberlain, Stanley
2011.
Phosphorodiamidates as a promising new phosphate prodrug motif for antiviral drug discovery: application to anti-HCV agents.
Journal of Medicinal Chemistry
54
(24)
, pp. 8632-8645.
10.1021/jm2011673
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McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Madela, Karolina, Aljarah, Mohamed, Gilles, Arnaud, Battina, S. K., Ramamurty, C. V. S., Rao, C. S., Vernachio, J., Hutchins, J., Hall, A., Kolykhalov, A., Henson, G. and Chamberlain, S.
2011.
Dual pro-drugs of 2 '-C-methyl guanosine monophosphate as potent and selective inhibitors of hepatitis C virus.
Biorganic and Medicinal Chemistry Letters
21
(19)
, pp. 6007-6012.
10.1016/j.bmcl.2011.06.013
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Hutchins, Jeff T., McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Chamberlain, Stanley D., Madela, Karolina W., Aljarah, Mohamed, Vernachio, John, Patti, Joseph M. and Henson, Geoffrey
2011.
DMPK and Metabolism Studies of Nucleoside Phosphoramidates Including INX-08189, A Novel Double Pro-drug and Clinical Candidate for Hepatitis C Virus Therapy.
Antiviral Research
90
(2)
, A22-A23.
10.1016/j.antiviral.2011.03.006
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Vernachio, John H., Bleiman, Blair, Bryant, K. Dawn, Chamberlain, Stanley, Hunley, Damound, Hutchins, Jeff, Ames, Brenda, Gorovits, Elena, Ganguly, Babita, Hall, Andrea, Kolykhalov, Alexander, Liu, Yule, Muhammad, Jerry, Raja, Nicholas, Walters, C. Robin, Wang, Jin, Williams, Karen, Patti, Joseph M., Henson, Geoffrey, Madela, Karolina, Aljarah, Mohamed, Gilles, Arnaud and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X
2011.
INX-08189, a phosphoramidate prodrug of 6-O-Methyl-2'-C-Methyl Guanosine, is a potent inhibitor of Hepatitis C virus replication with excellent pharmacokinetic and pharmacodynamic properties.
Antimicrobial Agents and Chemotherapy
55
(5)
, pp. 1843-1851.
10.1128/AAC.01335-10
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Vernachio, J., Bryant, D., Chamberlain, S. D., Gorovits, E., Ganguly, B. S., Hall, A., Henson, G. W., Hunley, D. S., Hutchins, J. T., Muhammad, J., Patti, J., Walters, C. R., Wang, J., Madela, Karolina, Aljarah, Mohamed, Jones, Sarah Louise and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X
2010.
In vitro and in vivo metabolism of INX-189, a potent HCV inhibitor, in rat and cynomolgus monkey hepatocytes [Abstract].
Hepatology
52
(S1)
, 1218A-1219A.
10.1002/hep.23997
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Hall, A., Raja, N., Chamberlain, S. D., Gorovits, E., Henson, G. W., Hutchins, J. T., Muhammad, J., Patti, J., Vernachio, J., Wang, J., Madela, Karolina, Aljarah, Mohamed, Jones, Sarah Louise and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X
2010.
Metabolite characterization of INX-189, a potent HCV inhibitor, in fresh human primary hepatocytes and human liver and kidney cell lines [abstract 1874].
Hepatology
52
(S1)
, 1211A-1211A.
10.1002/hep.23996
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McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Madela, Karolina, Aljarah, Mohamed, Gilles, Arnaud, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Zonta, Nicola, Chamberlain, Stanley, Vernachio, John, Hutchins, Jeff and Hall, Andrea
2010.
Design, synthesis and evaluation of a novel double pro-drug: INX-08189. A new clinical candidate for hepatitis C virus.
Biorganic and Medicinal Chemistry Letters
20
(16)
, pp. 4850-4854.
10.1016/j.bmcl.2010.06.094
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McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Gilles, Arnaud, Madela, Karolina, Aljarah, Mohamed, Holl, Sabrina, Jones, Sarah Louise, Vernachio, John, Hutchins, Jeff, Ames, Brenda, Bryant, K. Dawn, Gorovits, Elena, Ganguly, Babita, Hunley, Damound, Hall, Andrea, Kolykhalov, Alexander, Liu, Yule, Muhammad, Jerry, Raja, Nicholas, Walters, Robin, Wang, Jin, Chamberlain, Stanley and Henson, Geoffrey
2010.
Phosphoramidate ProTides of 2'-C-Methylguanosine as highly potent inhibitors of hepatitis C virus. Study of their in vitro and in vivo properties.
Journal of Medicinal Chemistry
53
(13)
, pp. 4949-4957.
10.1021/jm1003792
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