Concise synthesis of artemisinin from a farnesyl diphosphate analogue

Tang, Xiaoping, Demiray, Melodi, Wirth, Thomas ORCID: https://orcid.org/0000-0002-8990-0667 and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2017. Concise synthesis of artemisinin from a farnesyl diphosphate analogue. Bioorganic & Medicinal Chemistry 26 (7) , pp. 1314-1319. 10.1016/j.bmc.2017.03.068

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Abstract

Artemisinin is one of the most potent anti-malaria drugs and many often-lengthy routes have been developed for its synthesis. Amorphadiene synthase, a key enzyme in the biosynthetic pathway of artemisinin, is able to convert an oxygenated farnesyl diphosphate analogue directly to dihydroartemisinic aldehyde, which can be converted to artemisinin in only four chemical steps, resulting in an efficient synthetic route to the anti-malaria drug.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Chemistry
Subjects:	Q Science > QD Chemistry
Uncontrolled Keywords:	Malaria, Artemisinin, Amorphadiene synthase, Dihydroartemisinic aldehyde, Dihydroartemisinic acid, Farnesyl diphosphate
Publisher:	Elsevier
ISSN:	0968-0896
Funders:	EPSRC and BBSRC
Date of First Compliant Deposit:	18 May 2017
Date of Acceptance:	4 April 2017
Last Modified:	04 May 2024 01:07
URI:	https://orca.cardiff.ac.uk/id/eprint/100679

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